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Binds to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV. This results in the formation of immature, noninfectious viral particles. Ospemifene: CYP3A4 Inhibitors Strong may increase the serum concentration of Ospemifene. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. exem.info prinivil

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In Phase I and II controlled trials, the following adverse events were reported significantly more frequently by those randomized to the arms containing Crixivan than by those randomized to nucleoside analogues: rash, upper respiratory infection, dry skin, pharyngitis, taste perversion. The dose of indinavir will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of indinavir. Indinavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control eg, condoms if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.

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Caucasian subjects consisting of six racial groups. ONGLYZA can be taken with or without food. Crixivan. There is increased potential for sildenafil-associated adverse events which include visual disturbances, hypotension, prolonged erection, and syncope. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Ixabepilone: CYP3A4 Inhibitors Strong may increase the serum concentration of Ixabepilone.

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Simeprevir: CYP3A4 Inhibitors Strong may increase the serum concentration of Simeprevir. If you have any questions about indinavir, please talk with your doctor, pharmacist, or other health care provider. Rossum AM, Niesters HGM, Geelen SPM et al. Clinical and virologic response to combination treatment with indinavir, zidovudine, and lamivudine in children with human immunodeficiency virus-1 infection: a multicenter study in the Netherlands. J Pediatr. QuiNIDine: Indinavir may increase the serum concentration of QuiNIDine.

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Deyton L. Importance of surrogate markers in evaluation of antiviral therapy for HIV infection. JAMA. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Vardenafil: CYP3A4 Inhibitors Strong may increase the serum concentration of Vardenafil. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. What are the possible side effects of ZERIT? Do not share needles or other injection equipment. ALERT: Find out about medicines that should NOT be taken with Crixivan. A Patient Package Insert PPI for Crixivan is available for patient information.

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Ruxolitinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ruxolitinib. Management: This combination should be avoided under some circumstances. See monograph for details. Parecoxib: CYP3A4 Inhibitors Strong may increase the serum concentration of Parecoxib. The underlying mechanism for the development of PI-related hyperglycemia has not been identified. It has been proposed that since PIs are peptidomimetic inhibitors, they may inhibit the conversion of proinsulin to insulin via the calcium-dependent endopeptidases. Peripheral insulin resistance may be involved, since impaired glucose tolerance has been reported in PI-treated subjects in one study. Patients receiving PI therapy should have blood glucose levels measured periodically. MEPRON suspension or aerosolized pentamidine. Patients receiving such a combination should also be monitored extra closely for signs or symptoms of hypotension. Indinavir is to be used only by the patient for whom it is prescribed. Do not share it with other people. When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking indinavir, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat. Agenerase amprenavir Capsules US prescribing information. GlaxoSmithKline May, 2005. It is very important that your doctor check your progress at regular visits to make sure that indinavir is working properly. Blood and urine tests may be needed to check for unwanted effects. CONTRAINDICATED due to an increased risk for serious reactions such as myopathy including rhabdomyolysis. ONGLYZA of 21 weeks. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring. Impact of Antiretroviral Therapy. Paricalcitol: CYP3A4 Inhibitors Strong may increase the serum concentration of Paricalcitol. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using trazodone, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain problems , slow heartbeat, QT prolongation in the family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. The recommended dose for adults is 800 mg every eight hours. astonin

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Toremifene. CYP3A4 Inhibitors Strong may increase the serum concentration of Toremifene. Tell your doctor right away if you develop symptoms of high such as increased thirst and urination. Talk with your health provider. Hélal A. HIV protease inhibitors and increased bleeding in hemophilia? Radotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Radotinib. Procoralan ivabradine hydrochloride summary of product characteristics. Les Laboratoires Servier March, 2015. Carcinogenicity studies were conducted in mice and rats. In mice, no increased incidence of any tumor type was observed. Therefore, get medical help right away if you develop any rash. OxyCODONE. CYP3A4 Inhibitors Strong may increase the serum concentration of OxyCODONE. Serum concentrations of the active metabolite oxymorphone may also be increased. Dose reduction of Crixivan to 600 mg every 8 hours is recommended when administering itraconazole concurrently. There were 798 deaths in the SAVOR trial. Calcium Channel Blockers Nondihydropyridine: Protease Inhibitors may decrease the metabolism of Calcium Channel Blockers Nondihydropyridine. Increased serum concentrations of the calcium channel blocker may increase risk of AV nodal blockade. Management: Avoid concurrent use when possible. If used, monitor for CCB toxicity. The manufacturer of atazanavir recommends a 50% dose reduction for diltiazem be considered. Do not take any other medicines without checking first with your doctor. To do so may increase the chance of side effects from indinavir or other medicines.

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HIV RNA assays or using other sample credits. Study conducted in subjects on maintenance. Elevated indirect bilirubin, infrequently associated with increased serum AST SGOT or ALT SGPT concentrations, reported. Brooks JI, Gallicano K, Garber G, Angel JB "Acute monoarthritis complicating therapy with indinavir. Genentech USA. Invirase saquinavir mesylate capsules and tablets prescribing information. South San Francisco, CA; 2012 Feb. HIV protease inhibitor. Clin Pharmacol Ther. Terheggen F, Frissen J, Weigel H, Schouten I, Brinkman K "Nail, hair and skin hyperpigmentation associated with indinavir therapy. Ibrutinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Ibrutinib. It may harm them. Tacrolimus Topical: Protease Inhibitors may decrease the metabolism of Tacrolimus Topical. High levels of also increase the risk for calcium stones. generic condyline buy online australia

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The clinical significance of these gender differences in the pharmacokinetics of indinavir is not known. If it is almost time for your next dose, skip the missed dose. ZERIT that is written for health professionals. Rietsema WJ. Fever, erythroderma, abdominal pain, and renal failure following initiation of indinavir therapy. Clin Inf Dis. Who should not take ZERIT?

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Janssen. Prezista darunavir prescribing information. Titusville, NJ; 2012 Feb. Brinzolamide: CYP3A4 Inhibitors Strong may increase the serum concentration of Brinzolamide. Mild to moderate hepatic impairment due to cirrhosis: 600 mg every 8 hours. Apixaban: CYP3A4 Inhibitors Strong may increase the serum concentration of Apixaban. Patients with renal or hepatic impairment should not be given colchicine with Crixivan. Fang G, Siegal FP, Weiser B et al. Measurement of human immunodeficiency virus HIV type 1 RNA load distinguishes progressive from non-progressive HIV infection. Clin Infect Dis. Cases of acute spontaneous bleeding in hemophiliacs may be associated with protease inhibitors in general. Lovastatin: CYP3A4 Inhibitors Strong may increase the serum concentration of Lovastatin. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. order naprosyn online legal

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Squibb Pharmaceuticals January 8, 2004. Invirase saquinavir mesylate US prescribing information. Brigatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Brigatinib. Management: Avoid concurrent use of brigatinib with strong CYP3A4 inhibitors when possible. If combination cannot be avoided, reduce the brigatinib dose by approximately 50%, rounding to the nearest tablet strength ie, from 180 mg to 90 mg, or from 90 mg to 60 mg. Some medicines can cause dangerous or life-threatening side effects when used with indinavir. Upjohn Company August, 2012. Pacanowski J, Poirier JM, Petit I, Meynard JL, Girard PM "Atazanavir urinary stones in an HIV-infected patient. In mice, no increased incidence of any tumor type was observed. Midostaurin: CYP3A4 Inhibitors Strong may increase the serum concentration of Midostaurin. Management: Seek alternatives to the concomitant use of midostaurin and strong CYP3A4 inhibitors if possible. If concomitant use cannot be avoided, monitor patients for increased risk of adverse reactions. The trademarks depicted herein are owned by their respective companies. ONGLYZA should be administered following hemodialysis. HIV protease inhibitor. J Med Chem. Condra JH, Holder DJ, Schleif WA et al. Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor. J Virol. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Rhone-Poulenc Rorer Pharmaceuticals Inc. Drusano GL, Bilello JA, Stein DS et al. Factors influencing the emergence of resistance to indinavir: role of virologic, immunologic, and pharmacologic variables. J Infect Dis.

Important information

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. AIDS. However, current scientific information indicates that smoking or inhaling marijuna might not be safe. Talk with your healthcare provider before using this product. It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. ONGLYZA 5 mg 13. Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. differin

ONGLYZA might need to be changed

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Whitehouse Station, NJ 08889, USA. If you will be confined to a chair or bed for a long period of time eg, a long plane flight notify your doctor 3 to 4 weeks in advance. Special precautions may be needed. Available as indinavir sulfate; dosage expressed as indinavir. ONGLYZA and each time you get a refill. There may be new information. Crixivan must be taken at intervals of 8 hours. For optimal absorption, Crixivan should be administered without food but with water 1 hour before or 2 hours after a meal.

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No dosage adjustment is recommended based on gender. Bristol-Myers Squibb. Videx EC didanosine delayed-release capsules enteric-coated beadlets prescribing information. Princeton, NJ; 2011 Nov. Collier AC, Coombs RW, Schoenfeld DA et al et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med. Therapy with indinavir should be administered cautiously in patients with a current or past history of nephrolithiasis. It is crucial that patients receive adequate hydration. Study conducted in HIV-positive subjects. FDA pregnancy category B. Alosetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Read the Patient Information Leaflet provided by your pharmacist before you start taking indinavir and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Patients should be closely monitored for symptoms of pancreatitis. Do not keep outdated medicine or medicine no longer needed. Crixivan dose of 800 mg every 8 hours with zidovudine 200 mg every 8 hours and lamivudine 150 mg twice a day has been studied in 16 HIV-infected pregnant patients at 14 to 28 weeks of gestation at enrollment study PACTG 358. Do not share it with other people. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. CRIXIVAN alone vs. zidovudine plus lamivudine. buy olmesartan pico perles

Indinavir warnings

Tytgat GN, Jansen PL, Oude Elferink RP, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. Following 1-hour IV infusion. ONGLYZA 5 mg or placebo. Reyataz atazanavir sulfate US prescribing information. Bristol-Myers Squibb Company March, 2015. It is unknown if this medication passes into milk. Because milk can transmit HIV, not breast-feed. HIV-infected adults. AIDS Clinical Trials Group protocols 150 and 258. Ann Intern Med. Plasma concentrations may be increased by Crixivan.

What other drugs will affect indinavir

What are the possible side effects of indinavir Crixivan? Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates. Management: Concurrent use of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring. Indinavir is not a cure for HIV infection. Fung HB, Pecini RA, Brown ST, Gropper CA "Indinavir-associated maculopapular eruption. F. Do not freeze. Miller KD, Jones E, Yanovski JA et al. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Janssen. Intelence etravirine tablets prescribing information. Raritan, NJ; 2012 Mar. Use and dose must be determined by your doctor. HIV-infected women not planning a pregnancy may use any available type of contraception, considering possible drug interactions and contraindications of the specific method. In addition, consistent use of condoms is also recommended even during pregnancy to prevent transmission of HIV or other sexually transmitted diseases. Relative to indinavir 800 mg three times daily alone. Some patients treated with Crixivan developed kidney stones. In some of these patients this led to more severe kidney problems, including kidney failure or inflammation of the kidneys or kidney infection which sometimes spread to the blood. Drinking at least six 8-ounce glasses of liquids preferably water each day should help reduce the chances of forming a kidney stone see . Call your doctor or other health care provider if you develop kidney pains middle to lower stomach or back pain or blood in the urine. can you clomipramine in uk

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Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. No dosage adjustment is recommended based on age alone. Only take medicine that your doctor has prescribed specially for you. Do not share your medicine with others. Feigal DW Jr. Dear healthcare provider letter: HIV protease inhibitors and patients with hemophilia. ranolazine

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HIV-1 infection, including opportunistic infections. Spontaneous bleeding episodes have been reported in hemophiliac patients while receiving protease inhibitors. No causal relationship has been established, however, hemophiliacs should be monitored closely for bleeding during protease inhibitor therapy. Alfuzosin: Protease Inhibitors may increase the serum concentration of Alfuzosin.

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If you wear contact lenses and you develop problems with them, contact your doctor. As your gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time soon after starting or many months later. Agouron Pharmaceuticals, La Jolla, CA: Personal communication. Imatinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Imatinib. ONGLYZA and seek medical advice promptly.

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Bouscarat F, Bouchard C, Bouhour D "Paronychia and pyogenic granuloma of the great toes in patients treated with indinavir. St. John's wort, drugs used to treat such as phenytoin among others. Adverse events were observed in some animal reproduction studies. Placental passage in humans with unboosted dosing is minimal. No increased risk of overall birth defects has been observed according to data collected by the antiretroviral pregnancy registry. A small increased risk of preterm birth has been associated with maternal use of protease inhibitor-based combination antiretroviral therapy during pregnancy; however, the benefits of use generally outweigh this risk and protease inhibitors PIs should not be withheld if otherwise recommended. Information related to stillbirth, low birth weight, and small for gestational age infants is limited. Long-term follow-up is recommended for all infants exposed to antiretroviral medications; children who develop significant organ system abnormalities of unknown etiology particularly of the CNS or heart should be evaluated for potential mitochondrial dysfunction. Hyperbilirubinemia may occur in neonates following in utero exposure to indinavir. Hyperglycemia, new onset of diabetes mellitus, or diabetic ketoacidosis have been reported with PIs; it is not clear if pregnancy increases this risk.

Using dexamethasone together with indinavir may alter the effects of both medications. Contact your doctor if you experience thinning skin, easy bruising, changes in the shape or location of body fat especially in your face, neck, back, and waist increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. In addition, combining these medications can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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